Introduction Patient set-up optimization is required in radiotherapy to fill the accuracy gap between personalized treatment planning and uncertainties in the irradiation set-up. In this study. we aimed to develop a new method based on neural network to estimate patient geometrical setup using 4-dimensional (4D) XCAT anthropomorphic phantom. Materials and Methods To access 4D modeling... https://www.cubiertasytubulares.com/product-category/rice/