Introduction: Gliomas are the most common primary tumors of the central nervous system and. according to their malignancy. they are graded from I to IV. Recent studies have found that there is an association between gliomas and mutations in exon 4 of genes that codify for isocitrate dehydrogenases 1 and 2 (IDH1: codon 132; IDH2: codon 172). https://thehookahlabes.shop/product-category/tobacco/